95886-08-1Relevant academic research and scientific papers
Rational modification of Mannich base-type derivatives as novel antichagasic compounds: Synthesis, in vitro and in vivo evaluation
Paucar, Rocío,Martín-Escolano, Rubén,Moreno-Viguri, Elsa,Azqueta,Cirauqui,Marín, Clotilde,Sánchez-Moreno, Manuel,Pérez-Silanes, Silvia
, p. 3902 - 3917 (2019/07/30)
The current chemotherapy against Chagas disease is inadequate and insufficient. A series of ten Mannich base-type derivatives have been synthesized to evaluate their in vitro antichagasic activity. After a preliminary screening, compounds 7 and 9 were sub
Synthesis of Heterocyclic Compounds: Part XXVI - 3,6-Diaryl-3,4-dihydro-1,3,2-oxazaphosphorin-2-oxides
Modak, A. S.,Gogte, V. N.,Tilak, B. D.
, p. 907 - 913 (2007/10/02)
3,4-Dihydro-1,3,2-oxazaphosphorin-2-oxides (4a-r) have been prepared by the interaction of aryl β-aryl/alkylaminoethyl ketones (3a-r) with POCl3/Et3N.Various reactions of these compounds, which represent a new ring system, are reported.Few of these compou
Synthesis and Reactions of 3,6-Diaryl-3,4-dihydro-1,3,2-oxazaphosphorin-2-oxides
Tilak, B. D.,Gogte, V.N.,Modak, A.S.
, p. 414 - 415 (2007/10/02)
Aryl β-arylaminoethyl ketones (1), when reacted with phosphorus oxychloride followed by treatment with triethylamine, afford 3,6-diaryl-2-chloro-3,4-dihydro-1,3,2-oxazaphosphorin-2-oxides (3a-u), a hitherto unreported ring system.The oxazaphosphorin (3q), viz. 2-chloro-3-m-anisyl-6-phenyl-3,4-dihydro-1,3,2-oxazaphosphorin, is converted into 7-methoxy-4-phenylquinoline on keeping.This transformation is specific to 3q since other oxazaphosphorins fail to give the quinoline derivative.
