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Usage

Uses

Used in Organic Synthesis:
1,4-Bis(4-bromophenyl)buta-1,3-diyne serves as a key intermediate in organic synthesis, utilized for the creation of more intricate molecular structures. Its presence in the synthesis process is attributed to its reactivity and the ability to participate in multiple chemical reactions, which is instrumental in developing a diverse range of organic compounds.
Used in Material Science:
In the realm of material science, 1,4-Bis(4-bromophenyl)buta-1,3-diyne is employed as a component in the development of new materials. Its unique structure and properties make it a promising candidate for contributing to advancements in material technology, potentially leading to the creation of novel materials with enhanced characteristics.
Used in Pharmaceutical Research:
1,4-Bis(4-bromophenyl)buta-1,3-diyne is also utilized in pharmaceutical research as a target for the development of new drugs. Its distinctive chemical properties and reactivity offer opportunities for the design and synthesis of innovative pharmaceutical agents, which could address various medical needs and contribute to the advancement of healthcare solutions.

Upstream product

• 7647-01-0 hydrogenchloride 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 566163-88-0 methyl ester of N-(tert-butoxycarbonyl)-β,β-dibromodehydroalanine 
• 50-00-0 formaldehyd 
• 108-18-9 diisopropylamine 
• 768-60-5 4-methoxyphenylacetylen 
• 552-16-9 ortho-nitrobenzoic acid 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 613-91-2 acetophenone oxime 
• 108-24-7 acetic anhydride 
• 75230-51-2 4-bromoacetophenone tosylhydrazone 
• 51556-09-3 1-bromo-4-(chloroethynyl)benzene 
• 1066-54-2 trimethylsilylacetylene 
• 25294-65-9 3-(4-bromophenyl)-2-propynoic acid 

Downstream Products

• 13904-57-9 2,5-bis(p-bromophenyl)-1-phenyl-phosphole 
• 63574-85-6 2,5-Bis(p-bromophenyl)thiophene 
• 1415923-47-5 2,5-bis(4'-tert-butyl-4-biphenyl)thiophene 
• 1415923-46-4 2,5-bis(4'-isopropyl-4-biphenyl)thiophene 
• 23833-56-9 1,4-bis(4-(E)-styrylphenyl)buta-1,3-diyne 
• 1415923-44-2 1,4-bis(4'-cyano-4-biphenyl)buta-1,3-diyne 
• 1415923-43-1 1,4-bis(4'-acetyl-4-biphenyl)buta-1,3-diyne 
• 1415923-42-0 1,4-bis(4'-fluoro-4-biphenyl)buta-1,3-diyne 
• 1415923-41-9 1,4-bis(4'-(dimethylamino)-4-biphenyl)buta-1,3-diyne 
• 1415923-40-8 1,4-bis(4'-methoxy-4-biphenyl)buta-1,3-diyne 
• 70079-12-8 1,4-bis(4'-tert-butyl-4-biphenyl)buta-1,3-diyne 
• 1415923-39-5 1,4-bis(4'-isopropyl-4-biphenyl)buta-1,3-diyne 
• 1415923-38-4 1,4-bis(4’-methyl-4-biphenyl)buta-1,3-diyne 
• 1374219-42-7 5-(4-bromobenzyl)-3-(4-bromophenyl)isoxazole 

Relevant academic research and scientific papers

Synthesis of Functional 3-Buten-1-ynes and 1,3-Butadienes with Silsesquioxane Moiety via Hydrosilylation of 1,3-Diynes

Highly effective procedures for the addition of one or two molecules of 1-dimethylsiloxy-3,5,7,9,11,13,15-heptaisobutylpentacyclo-[9.5.1.13,9.15,15.17,13]octasiloxane ((HSiMe2O)(i-Bu)7Si8O12, (1)) to the symmetrically 1,4-disubstituted 1,3-diynes have been successfully developed for the first time. As a result, novel silsesquioxanes bearing substituents such as CH3, t-Bu, (CH3)2OSi(CH3)3, C6H5, C6H4Br-4, C6H4(BO2C2(CH3)4)-4, OH, COOCH3, and morpholino were obtained and characterized by 1H, 13C, 29Si NMR and mass spectrometry. Detailed optimization of reaction conditions was performed with a wide range of temperatures, in the presence of various types of catalysts and ratios of reagents, to obtain complex information about the process selectivity and develop efficient methods for synthesizing targeted compounds. It was found that precisely optimized approaches provided 3-buten-1-ynes or 1,3-butadienes with high yields, without decomposition of other reactive functionalities presented in the molecule structure. Due to the presence of reactive functional groups, the resulting compounds constituted a new silsesquioxane family characterized by unique structures and potential applications.

Red fluorescent luminogen from pyrrole derivatives with aggregation-enhanced emission for cell membrane imaging

A dye emitted red fluorescence with aggregation-enhanced emission properties was reported here. It can be utilized to specifically recognize the cell membrane of MCF-7 and 293T cell lines during bio-imaging. This journal is

Creating Dynamic Nanospaces in Solution by Cationic Cages as Multirole Catalytic Platform for Unconventional C(sp)?H Activation Beyond Enzyme Mimics

Herein we demonstrate that, based on the creation of dynamic nanospaces in solution by highly charged positive coordination cage of [Pd6(RuL3)8]28+, multirole and multi-way cage-confined catalysis is accomplisha

AIE compound, preparation method and application in detection of organic amine

The invention relates to the technical field of fluorescent materials, in particular to an AIE compound, a preparation method thereof and application of the AIE compound in organic amine detection. The structural general formula of the AIE compound is sho

Ligand and additive free aerobic synthesis of diynes using Pd-CuFe2O4magnetic nanoparticles as an efficient reusable catalyst

Herein, we present the synthesis of Pd-CuFe2O4 magnetic nanoparticles as an efficient and recyclable catalyst for the oxidative homocoupling of various terminal alkynes to form symmetric 1,3-diynes. The catalyst was found to be effective with very low palladium loading. The protocol has the advantages of easy synthesis of the catalyst, mild reaction conditions, short reaction times, excellent product yields and enhanced recyclability of the catalyst.

Transition-metal-free variant of Glaser- and Cadiot-Chodkiewicz-type Coupling: Benign access to diverse 1,3-diynes and related molecules

Efficient and transition-metal-free transformations towards the synthesis of 1,3-diynes have been described from their corresponding terminal acetylenes or 1,1-dibromo-1-alkenes. The efficiency of molecular iodine as catalyst in aqueous medium, driven the transformation to afford 1,3-diynes in moderate to good yields. The developed reaction conditions revealed appreciable functional group tolerance in aqueous medium. Further, the scope of the transition-metal-free approach for the synthesis of 1,3-enynes has been investigated using terminal alkynes as easy available precursors.

Tuning of cross-Glaser products mediated by substrate-catalyst polymeric backbone interactions

Tuning of cross-Glaser products using different polymeric backbones supported by copper oxide nano-catalysts has been demonstrated by tweaking the substrate-catalyst interactions under greener conditions. Further, highly reactive magnetically separable and recyclable catalyst with scalability is demonstrated.

Chemoselective Cobalt(I)-Catalyzed Cyclotrimerization of (Un)Symmetrical 1,3-Butadiynes for the Synthesis of 1,2,4-Regioisomers

The cobalt(I)-catalyzed cyclotrimerization of (un)symmetrical 1,4-disubstituted 1,3-butadiynes is presented. In the case of unsymmetrical 1,3-butadiynes, this reaction can generate eight 1,2,4-substituted and four 1,3,5-substituted isomers. A single 1,2,4-substituted isomer was formed in excellent yields (up to 99%) and exclusive regioselectivities (>99:1) when symmetrical or a 1,3-butadiyne with an aryl or alkyl substituent and a trimethylsilyl group were applied. A large number of products accepting a wide variety of functional groups were synthesized.

Stabilized Cu/Cu2O nanoparticles on rGO as an efficient heterogeneous catalyst for Glaser homo-coupling

Stabilized Cu/Cu2O nanoparticles on reduced graphene oxide (Cu/Cu2O-NPs@rGO) was synthesized by one-step co-reduction and acted as a green and efficient non-noble metal heterogeneous catalyst for Glaser homo-coupling. Through the synergic catalytic effect of Cu/Cu2O nanoparticles and graphene, the heterogeneous hybrid nanoparticles catalyst showed excellent catalytic performance for Glaser homo-coupling with the yield up to 99% of 1,4-diphenyl buta-1,3-diyne. And excellent functional group tolerance was obtained with oxygen as a green oxidant. Furthermore, the catalyst can be easily separated and recycled seven times without significant decline in its catalytic performance.

Copper (II) catalyzed homocoupling and heterocoupling of terminal alkynes

Cu(OTf)2 catalyzed homo– and heterocoupling of aromatic and aliphatic terminal alkynes has been developed. Symmetric and unsymmetric 1,3-diynes have been synthesized in good yields under an aerobic condition in the presence of an organic base D