95903-40-5

Basic information

• Product Name: 2H-1-Benzopyran-3-acetic acid, 7-hydroxy-4-methyl-2-oxo-8-propyl-, methyl ester
• CAS NO: 95903-40-5
• Molecular Formula: C16H18O5
• Molecular Weight: 290.316
• Mol File: 95903-40-5.mol

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-3-acetic acid, 7-hydroxy-4-methyl-2-oxo-8-propyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-3-acetic acid, 7-hydroxy-4-methyl-2-oxo-8-propyl-, methyl ester(95903-40-5)
• EPA Substance Registry System: 2H-1-Benzopyran-3-acetic acid, 7-hydroxy-4-methyl-2-oxo-8-propyl-, methyl ester(95903-40-5)

Safety Data

• Hazardous Substances Data: 95903-40-5(Hazardous Substances Data)

Upstream product

• 10420-33-4 dimethyl 2-acetylsuccinate 
• 13331-19-6 2-propyl-1,3-benzenediol 

Downstream Products

• 95903-41-6 methyl 7-((dimethylamino)thioxomethoxy)-4-methyl-2-oxo-8-propyl-2H-1-benzopyran-3-acetate 
• 108-95-2 phenol 

Relevant articles and documents

Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives

A small library of coumarin and their psoralen analogues EMAC10157a-b-d-g and EMAC10160a-b-d-g has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards carbonic anhydrase isoforms I, II, IX, and XII. None of the new compounds exhibited activity towards hCA I and II isozymes. Conversely, both coumarin and psoralen derivatives were active against tumour associated isoforms IX and XII in the low micromolar or nanomolar range of concentration. These data further corroborate our previous findings on analogous derivatives, confirming that both coumarins and psoralens are interesting scaffolds for the design of isozyme selective hCA inhibitors.

Leukotriene antagonists

Compounds having the formula: STR1 are antagonists of leukotrienes of C4, D4 and E4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory agents, and cytoprotective agents.

4-oxo-benzopyran carboxylic acids

Compounds of the Formula I: STR1 and pharmaceutically acceptable salts thereof are leukotriene antagonists. These compounds inhibit SRS-A and leukotriene synthesis and are antagonists of SRS-A and are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.