959151-12-3

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 51594-61-7 1-(3-methylphenyl)-2-propen-1-one 
• 591-17-3 meta-bromotoluene 
• 33802-51-6 α-methyl-β-phenylpropionitrile 
• 100-39-0 benzyl bromide 
• 51772-30-6 3'-Methylpropiophenone 

Relevant academic research and scientific papers

Iridium-Catalyzed Transfer Hydrogenation for Construction of Quinolines from 2-Aminobenzyl Alcohols with Enones in Water

Herein, we describe a method for the synthesis of functionalized quinolines from 2-aminobenzyl alcohols with -nsaturatedketones.This method exhibits tolerance to various functional groups and high efficiency, is environmentally benign, and can be performed on a gram scale. Control experiments suggest that this transformation is accomplished by iridium complex catalyzed transfer hydrogenation, which is then followed by Friedl nder cyclization. The results display that alkali is essential for the high selectivities of this catalytic system.

METHOD FOR PRODUCING QUINOLINE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing a quinoline compound which enhances manufacturing easiness and reduces manufacturing cost by positively utilizing iodine which is a resource capable of being produced in mass production especially in Japan. SOLUTION: There is provided a method for producing a quinoline compound by mixing an imine compound and an iodination agent, wherein R6 is an aliphatic group or an aromatic group; and R1 to R5 are a hydrogen atom, a halogen atom, an optionally substituted linear or branched alkyl group having 1 to 12 carbon atoms, an optionally substituted aromatic group, an optionally substituted non-aromatic heterocyclic group, a carboxyl group, a linear or branched alkoxy group having 1 to 12 carbon atoms, a phenoxy group, a cyano group or a nitro group, and may form an aromatic or non-aromatic ring by binding each other. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Preparation of 2-arylquinolines from β-arylpropionitriles with aryllithiums and NIS through iminyl radical-mediated cyclization

Treatment of β-arylpropionitriles with aryllithiums, followed by the reaction with water and then with NIS under irradiation with a tungsten lamp gave 2-arylquinolines in good to moderate yields. The present reaction proceeds through the formation of N-iodoimines from imines with NIS, the generation of imino-nitrogen-centered radicals, and their cyclization onto the aromatic rings of the imines to form 2-aryl-3,4-dihydroquinolines. Finally, the oxidation of 2-aryl-3,4-dihydroquinolines with NIS proceeds smoothly to generate 2-arylquinolines.

Enantioselective Metal-Free Hydrogenations of Disubstituted Quinolines

A metal-free hydrogenation of 2,4-disubstituted quinolines was realized for the first time using chiral diene derived borane catalysts to furnish the corresponding tetrahydroquinolines in 75-98% yields with 95/5-99/1 dr's and 86-98% ee's. This catalytic system was also effective for 2,3-disubstituted quinolines to give moderate to good ee's.

Red emitter complexes of IR(III) and devices made with such compounds

There are provided compounds of Formulae I and II: where: n is 1, 2 or 3;p is 0, 1 or 2;the sum of n +p is 3;R1 R2, R3 and R4 are each independently H, F, alkyl, trialkylsilyl, triarylsilyl, aryl or substituted