95923-25-4

Upstream product

• 87693-21-8 2-amino-N-(1H-tetrazol-5-yl)benzamide 
• 2258-42-6 formyl acetic anhydride 
• 610-14-0 2-nitrobenzyl chloride 
• 87693-28-5 2-nitro-N-(1H-tetrazol-5-yl)-benzamide 
• 118-48-9 isatoic anhydride 

Relevant academic research and scientific papers

3-(1H-Tetrazol-5-yl)-4(3H)-quinazolinone Sodium Salt (MDL 427): A New Antiallergic Agent

Syntheses for 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone sodium salt monohydrate (9; MDL 427) and the related formamido compound, 2-(formylamino)-N-1H-tetrazol-5-ylbenzamide (10), are described.Both compounds are active in the rat passive cutaneous anaphylaxis and passive peritoneal anaphylaxis tests.A 94:6 equilibrium mixture of 9 and ionized 10, respectively, forms in aqueous buffer systems at a pH-dependent rate.In addition, analogues of 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone (8) bearing substituents on the benzene ring, substituents at the 2-position, and heteroaryl groups at the 3-position other than tetrazole were prepared.These analogue sets demonstrated that an accessible electrophilic center and an acidic functionality were requirements for good antiallergic activity.

2-(Formylamino)-N-(1H-tetrazol-5-yl)benzamide and use as anti-allergics

2-(Formylamino)-N-(1H-tetrazol-5-yl)benzamide and its pharmaceutically acceptable salts are useful as antiallergic agents. The compounds are prepared by the reaction of 2-amino-N-(1H-tetrazol-5-yl)benzamide with formic acetic anhydride.