959237-01-5 Usage
Uses
Used in Pharmaceutical Industry:
5-Bromoquinazoline-2,4(1H,3H)-dione is used as a research compound for its potential anti-cancer properties, serving as a candidate for the development of new therapeutic agents. Its inhibitory effects on various enzymes and biological pathways make it a promising candidate for further exploration in cancer treatment.
Used in Medicinal Chemistry Research:
As a brominated quinazoline derivative, 5-Bromoquinazoline-2,4(1H,3H)-dione is utilized in the synthesis of new compounds and the study of structure-activity relationships in medicinal chemistry. Its unique structure allows for the investigation of its interactions with biological targets, which can lead to the discovery of novel drugs with improved efficacy and selectivity.
Used in Enzyme Inhibition Studies:
5-Bromoquinazoline-2,4(1H,3H)-dione is employed as a tool in enzyme inhibition studies to understand its effects on specific enzymes that may be implicated in various diseases, including cancer. This can provide insights into the development of targeted therapies that exploit these enzyme interactions.
Used in Biological Pathway Modulation:
5-BroMoquinazoline-2,4(1H,3H)-dione is used to modulate biological pathways that are critical in disease processes, particularly in cancer. By studying its effects on these pathways, researchers can gain a better understanding of the mechanisms underlying its potential therapeutic effects and identify new targets for intervention.
Used in Synthetic Chemistry:
Due to the presence of bromine in its structure, 5-Bromoquinazoline-2,4(1H,3H)-dione is used in synthetic chemistry for the preparation of other brominated compounds and as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Its reactivity and the ease of functional group manipulation make it a versatile building block in organic synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 959237-01-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,9,2,3 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 959237-01:
(8*9)+(7*5)+(6*9)+(5*2)+(4*3)+(3*7)+(2*0)+(1*1)=205
205 % 10 = 5
So 959237-01-5 is a valid CAS Registry Number.
959237-01-5Relevant academic research and scientific papers
DIACYLGLYCEROL KINASE MODULATING COMPOUNDS
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Paragraph 1331, (2021/07/02)
The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
Discovery of 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent IKur Inhibitor
Finlay, Heather J.,Johnson, James A.,Lloyd, John L.,Jiang, Ji,Neels, James,Gunaga, Prashantha,Banerjee, Abhisek,Dhondi, Naveen,Chimalakonda, Anjaneya,Mandlekar, Sandhya,Conder, Mary Lee,Sale, Harinath,Xing, Dezhi,Levesque, Paul,Wexler, Ruth R.
, p. 831 - 834 (2016/10/12)
A new series of phenylquinazoline inhibitors of Kv 1.5 is disclosed. The series was optimized for Kv 1.5 potency, selectivity versus hERG, pharmacokinetic exposure, and pharmacodynamic potency. 5-Phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine (13k) was identified as a potent and ion channel selective inhibitor with robust efficacy in the preclinical rat ventricular effective refractory period (VERP) model and the rabbit atrial effective refractory period (AERP) model.
QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS
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, (2011/04/14)
A compound of formula (I) wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.
