959372-77-1Relevant academic research and scientific papers
Benzimidazole-based antibacterial agents against Francisella tularensis
Kumar, Kunal,Awasthi, Divya,Lee, Seung-Yub,Cummings, Jason E.,Knudson, Susan E.,Slayden, Richard A.,Ojima, Iwao
, p. 3318 - 3326 (2013/07/05)
Francisella tularensis is a highly virulent pathogenic bacterium. In order to identify novel potential antibacterial agents against F. tularensis, libraries of trisubstituted benzimidazoles were screened against F. tularensis LVS strain. In a preliminary
Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents
Kumar, Kunal,Awasthi, Divya,Lee, Seung-Yub,Zanardi, Ilaria,Ruzsicska, Bela,Knudson, Susan,Tonge, Peter J.,Slayden, Richard A.,Ojima, Iwao
, p. 374 - 381 (2011/03/18)
Libraries of novel trisubstituted benzimidazoles were created through rational drug design. A good number of these benzimidazoles exhibited promising MIC values in the range of 0.5-6 μg/mL (2-15 μM) for their antibacterial activity against Mtb H37Rv strai
