7221-27-4

Usage

Uses

Used in Chemical Synthesis:
4-Amino-3,5-dinitrobenzoic Acid is used as a key intermediate in the synthesis of various chemical compounds. Its unique functional groups allow for versatile reactions, making it a valuable component in the production of dyes and other specialty chemicals.
Used in Dye Production:
In the dye industry, 4-Amino-3,5-dinitrobenzoic Acid is used as a precursor for the synthesis of dyes. Its chemical structure provides the necessary building blocks for creating a wide range of colors and properties in dye molecules, contributing to the development of new and improved dyes for various applications.
Used in Advanced Research:
4-Amino-3,5-dinitrobenzoic Acid is employed as a highly specific scientific unit in advanced research settings. Its unique chemical properties make it an ideal candidate for studying various chemical reactions and processes, as well as for use in the development of new materials and compounds with potential applications in various industries.

InChI:InChI=1/C7H5N3O6/c8-6-4(9(13)14)1-3(7(11)12)2-5(6)10(15)16/h1-2H,8H2,(H,11,12)

Upstream product

• 85365-92-0 3,5-dinitro-4-methoxybenzoic acid 
• 6393-42-6 4-methyl-2,6-dinitroaniline 
• 860698-40-4 4-ethoxy-3,5-dinitro-benzoic acid ethyl ester 
• 33927-13-8 4-(4-hydroxy-phenoxy)-3,5-dinitro-benzoic acid 
• 577-52-6 4-bromo-3,5-dinitrobenzoic acid 
• 7664-41-7 ammonia 
• 90325-30-7 3,4,5-trinitro-benzoic acid 
• 5326-34-1 4-Bromo-3-nitrotoluene 
• 118-97-8 4-chloro-3,5-dinitrobenzoic acid 
• 54321-79-8 4-amino-3,5-dinitrobenzamide 
• 74-11-3 para-chlorobenzoic acid 

Downstream Products

• 54226-19-6 4-Amino-3,5-dinitro-benzoesaeure-aethylester 
• 1019-52-9 4-hydroxy-3,5-dinitrobenzoic acid 
• 54226-22-1 3,4-diamino-5-nitrobenzoic acid 
• 618-77-9 3,4,5-triamino-benzoic acid 
• 51-39-8 3,4,5-trichlorobenzoic acid 
• 861782-46-9 3,5-dinitro-4-nitroamino-benzoic acid 
• 118-97-8 4-chloro-3,5-dinitrobenzoic acid 
• 7664-41-7 ammonia 
• 88-89-1 2,4,6-Trinitrophenol 
• 19013-22-0 ethyl 4-hydroxy-3,5-dinitrobenzoate 
• 99508-32-4 3,4,5-trichloro-benzoic acid amide 
• 42221-50-1 3,4,5-trichloro-benzoyl chloride 
• 120530-42-9 ethyl 3,4,5-trichlorobenzoate 
• 1072919-85-7 4-amino-3,5-dinitro-benzoyl chloride 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 1,3-dideazapurine-like 7-amino-5-hydroxymethyl-benzimidazole ribonucleoside analogues as aminoacyl-tRNA synthetase inhibitors

Aminoacyl-tRNA synthetases (aaRSs) have become viable targets for the development of antimicrobial agents due to their crucial role in protein translation. A series of six amino acids were coupled to the purine-like 7-amino-5-hydroxymethylbenzimidazole nucleoside analogue following an optimized synthetic pathway. These compounds were designed as aaRS inhibitors and can be considered as 1,3-dideazaadenine analogues carrying a 2-hydroxymethyl substituent. Despite our intentions to obtain N1-glycosylated 4-aminobenzimidazole congeners, resembling the natural purine nucleosides glycosylated at the N9-position, we obtained the N3-glycosylated benzimidazole derivatives as the major products, resembling the respective purine N7-glycosylated nucleosides. A series of X-ray crystal structures of class I and II aaRSs in complex with newly synthesized compounds revealed interesting interactions of these “base-flipped” analogues with their targets. While the exocyclic amine of the flipped base mimics the reciprocal interaction of the N3-purine atom of aminoacyl-sulfamoyl adenosine (aaSA) congeners, the hydroxymethyl substituent of the flipped base apparently loses part of the standard interactions of the adenine N1 and the N6-amine as seen with aaSA analogues. Upon the evaluation of the inhibitory potency of the newly obtained analogues, nanomolar inhibitory activities were noted for the leucine and isoleucine analogues targeting class I aaRS enzymes, while rather weak inhibitory activity against the corresponding class II aaRSs was observed. This class bias could be further explained by detailed structural analysis.

Benzimidazole-based antibacterial agents against Francisella tularensis

Francisella tularensis is a highly virulent pathogenic bacterium. In order to identify novel potential antibacterial agents against F. tularensis, libraries of trisubstituted benzimidazoles were screened against F. tularensis LVS strain. In a preliminary

Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents

Libraries of novel trisubstituted benzimidazoles were created through rational drug design. A good number of these benzimidazoles exhibited promising MIC values in the range of 0.5-6 μg/mL (2-15 μM) for their antibacterial activity against Mtb H37Rv strai

BENZIMIDAZOLES AND PHARMACEUTICAL COMPOSITIONS THEREOF

The present invention relates to novel benzimidazole derivatives and pharmaceutically acceptable salts thereof. Another aspect of the invention relates to methods of treating a patient infected by Mycobacterium tuberculosis or Francisella tulerensis by ad

Hydrogenation on palladium-containing granulated catalysts 3. Synthesis of aminobenzimidazoles by catalytic hydrogenation of dinitroanilines

Efficient hydrogenation of o-aminonitrobenzenes on palladium-containing granulated carbon catalysts in carboxylic acid solutions was accompanied by cyclization into aminobenzimidazoles. A simple hydrogenation reactor with a fixed gauze holding a reusable granulated catalyst was designed. Acylated and sulfonylated 4(7)-aminobenzimidazoles were obtained. In terms of electronic and geometrical parameters, they are close analogs of biologically active imidazo[1,5,4-e,f ][1,5]benzodiazepines.