959402-89-2Relevant academic research and scientific papers
Highly regioselective ring opening of quinolinic[2,3]anhydrides under mild conditions
Metobo, Sammy E.,Jabri, Salman Y.,Aktoudianakis, Evangelos,Evans, Jared,Jin, Haolun,Kim, Choung U.
, p. 6782 - 6784 (2013)
We report a study of the influence of Lewis acids upon the regioselectivity of ring opening of quinolinic[2,3]anhydrides to provide 2-(isopropoxycarbonyl)- nicotinic acids. In the presence of stoichiometric amounts of indium trifluoromethanesulfonate or lanthanum trifluoromethanesulfonate, the desired 2-position ester was generated with greater than 95:5 regioselectivity. This methodology was also applied to 6-methyl-[2,3]-quinoline to provide similar results.
ANTIVIRAL COMPOUNDS
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Page/Page column 26-27, (2010/02/17)
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Integrase inhibitors
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Page/Page column 40, (2008/06/13)
Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
