959631-88-0

Upstream product

• 87808-49-9 2-bromo-4-methyl-benzoic acid methyl ester 
• 24850-33-7 allyltributylstanane 

Downstream Products

• 959631-89-1 4-methyl-2-(2-oxo-ethyl)-benzoic acid methyl ester 
• 89044-48-4 2,5-dimethyl-2,3-dihydro-1H-inden-1-one 
• 1228095-13-3 2-[2-({4-[2-(2,6-dichloro-phenyl)-4-isopropyl-2H-pyrazol-3-ylmethoxy]-2-methyl-phenyl}-methyl-amino)-ethyl]-5-methyl-benzoic acid methyl ester 

Relevant academic research and scientific papers

Nickel-Catalyzed Domino Heck-Type Reactions Using Methyl Esters as Cross-Coupling Electrophiles

While esters are frequently used as traditional electrophiles in substitution chemistry, their application in cross-coupling chemistry is still in its infancy. This work demonstrates that methyl esters can be used as coupling electrophiles in Ni-catalyzed Heck-type reactions through the challenging cleavage of the C(acyl)?O bond under relatively mild reaction conditions at either 80 or 100 °C. With the σ-NiII intermediate generated from the insertion of acyl NiII species into the tethered C=C bond, carbonyl-retentive products were formed by domino Heck/Suzuki–Miyaura coupling and Heck/reduction pathways when organoboron and mild hydride nucleophiles are used.

Pyrazolopyrimidine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication

The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compound

FXR AGONISTS

Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.