959632-16-7

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 34328-46-6 4-chloro-3-(trifluoromethyl)benzaldehyde 
• 34328-47-7 4-dibromo-3-(trifluoromethyl)benzaldehyde 
• 959632-21-4 4-hydroxymethyl-2-trifluoromethylbenzoic acid methyl ester 

Downstream Products

• 1164268-60-3 4-(hydroxyimino-methyl)-2-trifluoromethyl-benzoic acid methyl ester 
• 1283119-35-6 4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyrimidin-4-yl)-2-(trifluoromethyl)benzoic acid 
• 1283119-38-9 methyl 4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyrimidin-4-yl)-2-(trifluoromethyl)benzoate 

Relevant academic research and scientific papers

PYRIMIDO[5,4-d]PYRIMIDINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS

The present invention relates to pyrimido[5,4-d]pyrimidine derivatives of formula (I), including pharmaceutically acceptable salts and solvates thereof. Compounds of the invention are inhibitors of ENT family transporter, especially of ENT1, and are useful as therapeutic compounds for the treatment of cancers. The invention also relates to the combined use of the pyrimido[5,4-d]pyrimidine derivatives with an adenosine receptor antagonist, for the treatment of cancers.

Synthesis method of 4-formyl-2-(trifluoromethyl) benzoic acid

The invention belongs to the technical field of medical intermediates and relates to a synthetic method of 4-formyl-2-(trifluoromethyl) benzoic acid. A compound A is used as an initial raw material; the compound A reacts with triethanolamine, PdCl2 (dppf) CH2Cl2 and the like, so that a compound B can be synthesized; a compound C is formed through the compound B; and the 4-formyl-2-(trifluoromethyl) benzoic acid is prepared from the compound C. The target product is synthesized by three steps; the synthesis route is short, the design is reasonable, the operation is simple, and the control is easy; the synthesis method of the 4-formyl-2-(trifluoromethyl) benzoic acid is provided for the first time, and the synthesis route is provided for the synthesis method of the 4-formyl-2-(trifluoromethyl) benzoic acid.

PYRAZOLE MAGL INHIBITORS

Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

PYRAZOLE MAGL INHIBITORS

Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.

INSECTICIDAL COMPOUNDS

A compound of formula (I), wherein A1, A2, A3, A4, G1, L, R1, R2, R3, R4, Y1, Y2 and Y3 are as defined in claim 1; or a sal

FXR AGONISTS

Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

COMPOUNDS AND METHODS FOR MODULATING FXR

Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.