959772-33-9Relevant academic research and scientific papers
Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice
Manetti, Fabrizio,Santucci, Annalisa,Locatelli, Giada A.,Maga, Giovanni,Spreafico, Adriano,Serchi, Tommaso,Orlandini, Maurizio,Bernardini, Giulia,Caradonna, Nicola P.,Spallarossa, Andrea,Brullo, Chiara,Schenone, Silvia,Bruno, Olga,Ranise, Angelo,Bondavalli, Francesco,Hoffmann, Oskar,Bologna, Mauro,Angelucci, Adriano,Botta, Maurizio
, p. 5579 - 5588 (2007)
New pyrazolo[3,4-d]pyrimidines were synthesized and found to inhibit Src phosphorylation in a cell-free assay. Some of them significantly reduced the growth of human osteogenic sarcoma (SaOS-2) cells. The best compound, in terms of inhibitory properties t
