959775-01-0Relevant academic research and scientific papers
RCM mediated synthesis of macrosphelides I and G
Sharma, Gangavaram V.M.,Veera Babu, Kagita
, p. 2175 - 2184 (2008/02/11)
The total synthesis of 16-membered macrolides, macraosphelides I and G, has been achieved starting from ethyl-(S)-lactate and (S)-malic acid. A combination of Jacobsen's hydrolytic kinetic resolution and Sharpless epoxidation is used for the creation of two stereogenic centres, while Yamaguchi esterification and ring-closing metathesis strategies were used for the construction of the lactone ring.
