959841-25-9Relevant academic research and scientific papers
Development of substituted 6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-ones as potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors active in BRCA deficient cells
Ferrigno, Federica,Branca, Danila,Kinzel, Olaf,Lillini, Samuele,Llauger Bufi, Laura,Monteagudo, Edith,Muraglia, Ester,Rowley, Michael,Schultz-Fademrecht, Carsten,Toniatti, Carlo,Torrisi, Caterina,Jones, Philip
, p. 1100 - 1105 (2010)
We describe an extensive SAR study in the 6-[4-fluoro-3-(substituted)benzyl]-4,5-dimethylpyridazin-3(2H)-one series which led to the identification of potent PARP-1 inhibitors, capable of inhibiting the proliferation of BRCA-1 deficient cancer cells in th
