959963-38-3Relevant academic research and scientific papers
Isolation, identification, semi-synthesis of aziditaxel derivatives and their biological evaluation
Zhang, Shu-En,Tao, Jia-Yi,Zhao, Ying,Wang, Shao-Rong,Zhou, Di,Fang, Wei-Shuo
, p. 463 - 475 (2012/07/14)
Two new taxoids (5 and 6) were obtained by isolating impurities in aziditaxel, and their structures were characterized based on data analysis of 1H NMR, 13C NMR, HPLC-MS, and through comparison with literature. In order to test their cytotoxicities against human nonsmall lung cancer cell lines (A549), sufficient amounts of compounds 5 and 6 were obtained by semi-synthesis and both of them showed equipotent cytotoxiesty compared with taxol, docetaxel, and aziditaxel.
Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport
Xiao, Xi,Wu, Ju,Trigili, Chiara,Chen, Hui,Chu, Joseph W.K.,Zhao, Ying,Lu, Peihua,Sheng, Li,Li, Yan,Sharom, Frances J.,Barasoain, Isabel,Diaz, J. Fernando,Fang, Wei-Shuo
, p. 4852 - 4856 (2011/09/21)
Some C-7 modified analogs of 3, a taxane with high affinity for binding to microtubules, were prepared through multistep transformations. Most of the analogs, bearing less lipophilic C-7 substituents than propionyl in 3, exhibited comparable binding affin
