1346575-94-7Relevant academic research and scientific papers
Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport
Xiao, Xi,Wu, Ju,Trigili, Chiara,Chen, Hui,Chu, Joseph W.K.,Zhao, Ying,Lu, Peihua,Sheng, Li,Li, Yan,Sharom, Frances J.,Barasoain, Isabel,Diaz, J. Fernando,Fang, Wei-Shuo
, p. 4852 - 4856 (2011/09/21)
Some C-7 modified analogs of 3, a taxane with high affinity for binding to microtubules, were prepared through multistep transformations. Most of the analogs, bearing less lipophilic C-7 substituents than propionyl in 3, exhibited comparable binding affin
