959984-64-6

Basic information

• Product Name: (2S,3aS,7a5)-octahydroindole-2-carboxylic acid p-nitrobenzylic ester p-toluenesulfonate
• Synonyms: (2S,3aS,7a5)-octahydroindole-2-carboxylic acid p-nitrobenzylic ester p-toluenesulfonate
• CAS NO: 959984-64-6
• Molecular Weight: 476.551
• Mol File: 959984-64-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3aS,7a5)-octahydroindole-2-carboxylic acid p-nitrobenzylic ester p-toluenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3aS,7a5)-octahydroindole-2-carboxylic acid p-nitrobenzylic ester p-toluenesulfonate(959984-64-6)
• EPA Substance Registry System: (2S,3aS,7a5)-octahydroindole-2-carboxylic acid p-nitrobenzylic ester p-toluenesulfonate(959984-64-6)

Safety Data

• Hazardous Substances Data: 959984-64-6(Hazardous Substances Data)

Upstream product

• 619-73-8 4-nitrobenzyl chloride 
• 80875-98-5 (2S,3aS,7aS)-perhydroindole-2-carboxylic acid 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 866430-96-8 (2S,3aS,7aS)-1-{2-[1-ethoxycarbonyl-(S)-butylamino]-(S)-propionyl}-octahydroindole-2-carboxylic acid p-nitrobenzylic ester 

Relevant articles and documents

Process for the preparation of perindopril and salts thereof

The present invention describes a novel method for the synthesis of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid, or of one of its aryl esters of formula XIII wherein X and Y are a hydrogen atom, a halogen, alkyl, alkoxyl or nitro group, and the conversion of the paranitrobenzyl ester of formula X into Perindopril of formula I or one of its salts.