959995-24-5Relevant academic research and scientific papers
Synthesis of substituted monohalobenzenes via ortho-selective cross-coupling of dihalobenzenes with electron-donating ortho-directing groups
Ishikawa, Shunpei,Manabe, Kei
, p. 3180 - 3182 (2008)
Dihalobenzenes that possess directing groups such as OH, CH2OH, NH2, NHAc, or NHBoc were subjected to ortho-selective cross-coupling with Grignard reagents in the presence of palladium-based catalysts to give the corresponding substituted monohalobenzenes. For the dibromo- and dichlorophenols and anilines, hydroxylated terphenylphosphines 1 and 2 were found to be effective ligands for palladium, whereas tricyclohexylphosphine was preferable for the dichlorobenzyl alcohols, dichloroanilides, and difluorobenzenes. Georg Thieme Verlag Stuttgart.
Highly ortho-selective cross-coupling of dichlorobenzene derivatives with grignard reagents
Ishikawa, Shunpei,Manabe, Kei
, p. 5593 - 5595 (2008/09/18)
Highly ortho-selective cross-coupling of dichlorobenzene derivatives with Grignard reagents was realized using a combination of Pd2(dba) 3 and PCy3. Use of hydroxylated terphenylphosphines further improved the reactions of dichiorophenol and dichloroaniline.
