959996-48-6

Usage

Uses

Used in Organic Synthesis:
2-Bromo-5-fluorobenzeneboronic acid is used as a reagent in organic reactions for the formation of carbon-carbon and carbon-heteroatom bonds. Its distinctive structure allows for the synthesis of complex organic molecules with potential applications in various fields.
Used in Medicinal Chemistry:
In the pharmaceutical industry, 2-Bromo-5-fluorobenzeneboronic acid is employed as a key intermediate in the synthesis of bioactive compounds. Its ability to form stable bonds with other molecules makes it a valuable component in the development of new drugs with specific therapeutic properties.
Used in Agrochemicals:
2-Bromo-5-fluorobenzeneboronic acid is utilized in the agrochemical industry as a building block for the synthesis of active ingredients in pesticides and other agricultural chemicals. Its reactivity and stability contribute to the creation of effective and environmentally friendly products.
Used in Materials Science:
In the field of materials science, 2-Bromo-5-fluorobenzeneboronic acid is used as a precursor for the preparation of novel materials with specific properties. Its unique structure and reactivity enable the development of advanced materials with potential applications in various industries, such as electronics, energy, and nanotechnology.

InChI:InChI=1/C6H5BBrFO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3,10-11H

Upstream product

• 202865-72-3 1-bromo-4-fluoro-2-iodobenzene 

Downstream Products

• 959996-47-5 3-(2-bromo-5-fluorophenyl)-1-(2-trimethylsilylethoxymethyl)pyrazole-4-carbaldehyde 
• 343-40-8 3-fluoro-9H-fluorene 
• 959996-53-3 (R)-N-((3-(2-bromo-5-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)(cyclopropyl)methyl)-6-(trifluoromethyl)pyridine-3-sulfonamide 
• 959997-63-8 (S)-4-cyclopropyl-8-fluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline 
• 1190854-16-0 (R)-4-cyclopropyl-8-fluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline 
• 959996-52-2 (R)-(3-(2-bromo-5-fluorophenyl)-1-((2-(trimethylsilyl)ethoxy)-methyl)-1H-pyrazol-4-yl)(cyclopropyl)methanamine 

Relevant academic research and scientific papers

Discovery of (R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl) phenylsulfonyl)-4,5-dihydro-1 H -pyrazolo[4,3- c ]quinoline (ELND006) and (R)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4, 5-dihydro-2 H -pyrazolo[4,3- c ]quinoline (ELND007): Metabolically stable γ-Secretase Inhibitors that selectively inhibit the production of amyloid-β over notch

Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of Aβ generation over Notch. We highlight our synthetic strategy to incorporate diversity and chirality. Compounds 30 (ELND006) and 34 (ELND007) both entered human clinical trials. The in vitro and in vivo characteristics for these two compounds are described. A comparison of inhibition of Aβ generation in vivo between 30, 34, Semagacestat 41, Begacestat 42, and Avagacestat 43 in mice is made. 30 lowered Aβ in the CSF of healthy human volunteers.

Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase

The invention provides compounds of formula I: or pharmaceutically salts thereof where R1, R2, and the A, B, and C-rings are as defined herein. Compounds of formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds or salts of formula I, methods of preparing the desired compounds, and methods of treating cognitive disorders, such as Alzheimer's disease, using the compounds or salts of formula I.