960128-72-7Relevant academic research and scientific papers
Highly enantioselective synthesis of α-hydroxy phosphonic acid derivatives by Rh-catalyzed asymmetric hydrogenation with phosphine- phosphoramidite ligands
Wang, Dao-Yong,Hu, Xiang-Ping,Huang, Jia-Di,Deng, Jun,Yu, Sai-Bo,Duan, Zheng-Chao,Xu, Xue-Feng,Zheng, Zhuo
, p. 7810 - 7813 (2008/09/19)
(Chemical Equation Presented) A class act: Unsymmetrical hybrid phosphine-phosphoramidite ligands with central and axial chirality are applied to the highly enantioselective hydrogenation of various enol ester phosphonates (see scheme; cod = cycloocta-1,5-diene). Enantioselectivities up to 99.9% ee are obtained for all classes of β-aryl, β-alkoxy, and β-alkyl substrates.
