87600-54-2

Upstream product

• 25026-34-0 4-chlorophenacetyl chloride 
• 121-45-9 phosphorous acid trimethyl ester 
• 1878-66-6 4-chlorophenylacetic Acid 

Downstream Products

• 960128-72-7 (E)-1-benzoyloxy-1-dimethoxyphosphoryl-2-(4-chlorophenyl)ethene 
• 1193615-60-9 C₁₇H₁₆ClO₅P 
• 1457935-49-7 (2R,3S)-2-(4-chlorophenyl)-N-methyl-4-nitro-3-phenylbutanamide 

Relevant academic research and scientific papers

Asymmetric hydrogenation of α- Or β-acyloxy α,β- unsaturated phosphonates catalyzed by a Rh(i) complex of monodentate phosphoramidite

The Rh(i) complex of a monodentate phosphoramidite bearing a primary amine moiety (DpenPhos) has been disclosed to be highly efficient for the asymmetric hydrogenation of a variety of α- or β-acyloxy α,β- unsaturated phosphonates, providing the corresponding biologically important chiral α- or β-hydroxy phosphonic acid derivatives with excellent enantioselectivities (90->99% ee).

Highly enantioselective synthesis of α-hydroxy phosphonic acid derivatives by Rh-catalyzed asymmetric hydrogenation with phosphine- phosphoramidite ligands

(Chemical Equation Presented) A class act: Unsymmetrical hybrid phosphine-phosphoramidite ligands with central and axial chirality are applied to the highly enantioselective hydrogenation of various enol ester phosphonates (see scheme; cod = cycloocta-1,5-diene). Enantioselectivities up to 99.9% ee are obtained for all classes of β-aryl, β-alkoxy, and β-alkyl substrates.