960130-67-0Relevant articles and documents
Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors
Manku, Sukhdev,Allan, Martin,Nguyen, Natalie,Ajamian, Alain,Rodrigue, Jacques,Therrien, Eric,Wang, James,Guo, Tim,Rahil, Jubrail,Petschner, Andrea J.,Nicolescu, Alina,Lefebvre, Sylvain,Li, Zuomei,Fournel, Marielle,Besterman, Jeffrey M.,Deziel, Robert,Wahhab, Amal
scheme or table, p. 1866 - 1870 (2009/11/30)
We have recently reported on a novel class of histone deacetylase (HDAC) inhibitors bearing a sulfamide group as the zinc-binding unit. Herein, we report on the synthesis of sulfamide based inhibitors designed around a lysine scaffold and their structure-