960130-68-1Relevant academic research and scientific papers
Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors
Manku, Sukhdev,Allan, Martin,Nguyen, Natalie,Ajamian, Alain,Rodrigue, Jacques,Therrien, Eric,Wang, James,Guo, Tim,Rahil, Jubrail,Petschner, Andrea J.,Nicolescu, Alina,Lefebvre, Sylvain,Li, Zuomei,Fournel, Marielle,Besterman, Jeffrey M.,Deziel, Robert,Wahhab, Amal
scheme or table, p. 1866 - 1870 (2009/11/30)
We have recently reported on a novel class of histone deacetylase (HDAC) inhibitors bearing a sulfamide group as the zinc-binding unit. Herein, we report on the synthesis of sulfamide based inhibitors designed around a lysine scaffold and their structure-
SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS
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Page/Page column 109, (2010/11/29)
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I), and racemic and scalemic mixtures, diastereomers and enantiomers thereof: or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, prodrug or complex thereof, wherein Y, L, Z, W, M, Ra, Rb and Rc are as defined in the specification.
