960137-80-8Relevant academic research and scientific papers
Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere via N-H imines as an intramolecular directing group
Zhang, Line,Ang, Gim Yean,Chiba, Shunsuke
supporting information; experimental part, p. 1622 - 1625 (2011/05/05)
Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere was developed starting from carbonitriles and Grignard reagents via N-H imine intermediates. The present process is characterized by the following two-step sequence in a one-pot manner: (1) addition of Grignard reagents to carbonitriles to form N-H imines and (2) benzylic C-H oxygenation (C=O bond formation) triggered by 1,5-hydrogen atom transfer with transient iminyl copper species.
A convergent synthesis of polysubstituted aromatic nitriles via palladium-catalyzed C-H functionalization
Mariampillai, Brian,Alliot, Julien,Li, Mengzhou,Lautens, Mark
, p. 15372 - 15379 (2008/09/18)
A palladium-catalyzed C-H functionalization reaction for the synthesis of highly substituted aromatic nitriles is reported. The modularity of the reaction is demonstrated by the broad range of aryl iodides which can be coupled with metal cyanides and alkyl halides or aryl bromides.
