96019-08-8Relevant academic research and scientific papers
Action des hydroxyurees sur les maleate et fumarate de methyle. Obtention des carbomethoxy-5 oxa-6 dihydrouraciles; transposition en carbomethoxymethylene-5 hydantoines
Bennouna, Chakib,Petrus, Francoise,Verducci, Jean,Hauw, Christian,Gaultier, Jacques
, p. 2891 - 2897 (2007/10/02)
We describe in this paper the Michael-type addition of hydroxyureas with methyl maleate and fumarate.The cyclization of the ureidoxyester intermediates obtained leads to the isolation of 5-carbomethoxy 6-oxadihydrouracils; their structure is proved by X-ray analysis.These relatively unstable compounds undergo transposition under basic conditions and give 5-carbomethoxyhydantoins.
