7335-35-5

Basic information

• Product Name: 1-hydroxy-3-phenylurea
• Synonyms: urea, N-hydroxy-N'-phenyl-
• CAS NO: 7335-35-5
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.1506
• Mol File: 7335-35-5.mol
• Article Data: 11

Chemical Properties

• Density: 1.354g/cm³
• Refractive Index: 1.65
• CAS DataBase Reference: 1-hydroxy-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-hydroxy-3-phenylurea(7335-35-5)
• EPA Substance Registry System: 1-hydroxy-3-phenylurea(7335-35-5)

Safety Data

• Hazardous Substances Data: 7335-35-5(Hazardous Substances Data)

Usage

Chemical Family

Urea family

Functional Groups

Urea group, hydroxyl group, and phenyl group

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Primary Purpose

Building block in the production of new drugs and pesticides

Ongoing Research

Potential biological activities and therapeutic properties

Upstream product

• 33026-77-6 N-(phenyl)-N'-phenylmethoxyurea 
• 62-53-3 aniline 
• 593-56-6 N-methoxylamine hydrochloride 
• 103-71-9 phenyl isocyanate 
• 1234457-71-6 C₁₁H₁₆N₂O₂ 
• 49622-07-3 chloromethyl N-phenylcarbamate 
• 101-42-8 fenuron 

Downstream Products

• 82255-32-1 C₁₅H₁₆N₂O₃ 
• 82255-39-8 C₂₃H₂₄N₂O₄ 
• 82255-33-2 C₁₃H₁₈N₂O₃ 
• 104308-42-1 4,5-dimethyl-N-phenyl-3,6-dihydro-2H-1,2-oxazine-2-carboxamide 
• 96019-08-8 2-Phenoxy-succinic acid dimethyl ester 
• 79834-09-6 [2,5-Dioxo-1-phenyl-imidazolidin-(4Z)-ylidene]-acetic acid methyl ester 
• 603-54-3 N,N-diphenylurea 
• 7803-49-8 hydroxylamine 
• 15719-64-9 methylammonium carbonate 
• 62-53-3 aniline 
• 1315572-59-8 N-(pivaloyloxy)-N'-phenylurea 
• 104308-48-7 N-hydroxy-N-(3-methyl-2-methylenebut-3-enyl)-N'-phenylurea 
• 1576-17-6 N-methoxy-N-methyl-N'-phenylurea 

Relevant articles and documents

1-methyl-1-methoxy-3-phenylurea synthetic method

The invention discloses a synthesis method of 1-methyl-1-methoxyl-3-phenylurea. The synthesis method comprises the following steps of carrying out gasification reaction of phenylamine and light in an organic solvent to obtain phenyl isocyanate; reacting an organic solvent solution of phenyl isocyanate with hydroxylamine sulphate in an alkaline aqueous solution in the presence of a catalyst A to obtain 1-hydroxyl-3-phenylurea; reacting 1-hydroxyl-3-phenylurea with dimethyl sulphate in the alkaline condition in the presence of a catalyst B to obtain 1-methyl-1-methoxyl-3-phenylurea. The synthesis method of 1-methyl-1-methoxyl-3-phenylurea has the advantages of being simple and direct in process, high in product purity, easy in control of production processes, and the like.

Investigating N-methoxy-N′-aryl ureas in oxidative C-H olefination reactions: An unexpected oxidation behaviour

Herein, we report a urea derived directing group for mild and highly selective oxidative C-H bond olefination. Subsequent intramolecular Michael addition affords dihydroquinazolinones in good yields. The N-O bond of the urea substrate exhibits superior oxidative behaviour compared to a variety of other external oxidants. The Royal Society of Chemistry 2011.

Analogues of N-hydroxy-N′-phenylthiourea and N-hydroxy-N′-phenylurea as inhibitors of tyrosinase and melanin formation

A series of N-hydroxy-N′-phenylthiourea and N-hydroxy-N′-phenylurea analogues were prepared and evaluated as inhibitors of tyrosinase and melanin formation. The most active analogue 1 inhibited mushroom tyrosinase with an IC50 of around 0.29 μM