96020-91-6 Usage
Uses
Used in Pharmaceutical Industry:
Eflornithine hydrochloride hydrate is used as an antineoplastic agent for its ability to inhibit the proliferation of cancer cells by targeting ornithine decarboxylase, an enzyme involved in polyamine biosynthesis.
Used in Antimalarial Applications:
Eflornithine hydrochloride hydrate is used as an antipneumocystic agent, effective against Pneumocystis jirovecii, a fungus that causes pneumonia in immunocompromised individuals.
Used in Antiprotozoal Applications:
Eflornithine hydrochloride hydrate is used as an antiprotozoal agent, particularly effective against Trypanosoma, a genus of parasitic protozoa that causes diseases such as African trypanosomiasis (sleeping sickness) and Chagas disease.
Used in Dermatological Applications:
Eflornithine hydrochloride hydrate is used as a treatment for hirsutism, a condition characterized by excessive hair growth in women, by inhibiting the enzyme ornithine decarboxylase, which is involved in hair follicle growth.
Used in Cancer Research:
Eflornithine hydrochloride hydrate is used as a research tool to study the role of ornithine decarboxylase in cancer cell proliferation and angiogenesis, as well as to investigate its potential synergistic effects with other chemotherapeutic drugs.
Biochem/physiol Actions
Primary TargetODC
References
1) Verma et al. (1990), Inhibition of tumor promotion by DL-alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase; Basic Life Sci., 52 195
2) Takahashi et al. (2000), Alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model; Int. J. Cancer, 85 243
3) Meyskens et al. (1999), Development of difluoromethylornithine (DFMO) as a chemoprevention agent; Clin. Cancer Res., 5 945
Check Digit Verification of cas no
The CAS Registry Mumber 96020-91-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,6,0,2 and 0 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 96020-91:
(7*9)+(6*6)+(5*0)+(4*2)+(3*0)+(2*9)+(1*1)=126
126 % 10 = 6
So 96020-91-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H12F2N2O2.ClH/c7-4(8)6(10,5(11)12)2-1-3-9;/h4H,1-3,9-10H2,(H,11,12);1H
