960207-27-6Relevant academic research and scientific papers
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain
Hoyt, Scott B.,London, Clare,Abbadie, Catherine,Felix, John P.,Garcia, Maria L.,Jochnowitz, Nina,Karanam, Bindhu V.,Li, Xiaohua,Lyons, Kathryn A.,McGowan, Erin,Priest, Birgit T.,Smith, McHardy M.,Warren, Vivien A.,Thomas-Fowlkes, Brande S.,Kaczorowski, Gregory J.,Duffy, Joseph L.
, p. 3640 - 3645 (2013)
A series of benzazepinones were synthesized and evaluated for block of Nav1.7 sodium channels. Compound 30 from this series displayed potent channel block, good selectivity versus other targets, and dose-dependent oral efficacy in a rat model of neuropathic pain.
Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain
Hoyt, Scott B.,London, Clare,Ok, Hyun,Gonzalez, Edward,Duffy, Joseph L.,Abbadie, Catherine,Dean, Brian,Felix, John P.,Garcia, Maria L.,Jochnowitz, Nina,Karanam, Bindhu V.,Li, Xiaohua,Lyons, Kathryn A.,McGowan, Erin,MacIntyre, D. Euan,Martin, William J.,Priest, Birgit T.,Smith, McHardy M.,Tschirret-Guth, Richard,Warren, Vivien A.,Williams, Brande S.,Kaczorowski, Gregory J.,Parsons, William H.
, p. 6172 - 6177 (2008/04/03)
A series of benzazepinones were synthesized and evaluated as hNav1.7 sodium channel blockers. Several compounds from this series displayed good oral bioavailability and exposure and were efficacious in a rat model of neuropathic pain.
BENZAZEPINONES AS SODIUM CHANNEL BLOCKERS
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Page/Page column 53; 57, (2008/06/13)
Benzazepinone compounds represented by Formula (I), or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically act
