22344-77-0

Upstream product

• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 160938-18-1 1-iodo-5-chloro-2-nitrobenzene 
• 22246-45-3 1,3,4,5-Tetrahydro-7-nitro-2H-benzazepin-2-on 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 68253-36-1 1-tetralone oxime 
• 22245-92-7 7-Amino-1,3,4,5-tetrahydro-2H-benzazepin-2-on 

Downstream Products

• 80452-55-7 7-chloro-1,3,4,5-tetrahydro-2H-1-benzazepine-2,5-dione 
• 960207-27-6 C₂₇H₃₃N₃O₄ClF 
• 87379-36-0 10-chloro-5,7-dihydro-2-methyl-7-phenylpyrimido<5,4-d>benzazepin-6(6H)-one 
• 879999-68-5 7-chloro-1-[2-nitrophenylsulfonyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 879999-67-4 7-chloro-1-(phenylsulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 313673-94-8 7-chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepine 

Relevant academic research and scientific papers

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model

Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent and sel

Oxidation of Nonactivated Anilines to Generate N-Aryl Nitrenoids

A low-temperature, protecting-group-free oxidation of 2-substituted anilines has been developed to generate an electrophilic N-aryl nitrenoid intermediate that can engage in C-NAr bond formation to construct functionalized N-heterocycles. The exposure of 2-substituted anilines to PIFA and trifluoroacetic acid or 10 mol percent Sc(OTf)3 triggers nitrenoid formation, followed by productive and selective C-NAr and C-C bond formation to yield spirocyclic- or bicyclic 3H-indoles or benzazepinones. Our experiments demonstrate the breadth of these oxidative processes, uncover underlying fundamental elements that control selectivity, and demonstrate how the distinct reactivity patterns embedded in N-aryl nitrenoid reactive intermediates can enable access to functionalized 3H-indoles or benzazepinones.

Synthesis of tetrahydrobenzazepinesulfonamides and their rearrangement to diarylsulfones

A new class of diarylsulfones, in which tetrahydrobenzazepine comprises one of the aromatic moieties, has been synthesized via the acid-catalyzed rearrangement of several substituted benzazepinesulfonamides. The rearrangement is normally ortho but in at l

Lipoxygenase Inhibitors, III: Synthesis of Tetrahydrobenzazepinone Phenylhydrazones

Tetrahydro-2H-benzazepin-2-ones as starting substances are synthesized by Beckmann rearrangement or Schmidt reaction.The tetrahydrobenzazepinones are transformed into the thiones, thiolactim ethers and phenylhydrazones.The compounds are tested as inhibitors of soja lipoxygenase.

Synthesis of 7-phenylpyrimido[5,4-d][1]benzazepin-2-ones

The syntheses of the 7-phenylpyrimido[5,4-d][1]benzazepin-2-ones 3, 4, and 5 are described. The 7-phenyl group was introduced by phenylation of the lactam nitrogen in 10, 13 and 16 respectively. One of these compounds, 5, showed moderate activity as a CNS agent.