960211-35-2

Upstream product

• 960211-10-3 (S)-1-((tert-butyldimethylsilyl)oxy)hept-5-yn-3-ol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 108794-10-1 4-[(tert-butyldimethylsilyl)oxy]-1-butene 
• 95337-97-6 (R)-2-(2-(tert-butyldimethylsilyloxy)ethyl)oxirane 
• 95337-97-6 2-[2-[[(tert-butyl)dimethylsilyl]oxy]ethyl]oxirane 

Downstream Products

• 960211-36-3 (S,Z)-5-(but-2-en-1-yl)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecane 
• 1165752-75-9 C₂₃H₃₀O₂Si 
• 960211-37-4 (S,Z)-3-((tert-butyldiphenylsilyl)oxy)hept-5-en-1-ol 
• 960211-38-5 (S,Z)-3-((tert-butyldiphenylsilyl)oxy)hept-5-enal 
• 960211-45-4 (S)-2-amino-N-((1Z,6Z)-4-((tert-butyldiphenylsilyl)ox-y)octa-1,6-dien-1-yl)-3,3-dimethylbutanamide 
• 960211-42-1 tert-butyl ((S)-1-(((S,1Z,6Z)-4-((tert-butyldiphenylsilyl)oxy)octa-1,6-dien-1-yl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate 
• 960211-47-6 (S)-N-((S,1Z,6Z)-4-((tert-butyldiphenylsilyl)oxy)octa-1,6-dien-1-yl)-3,3-dimethyl-2-((Z)-3-(tributylstannyl)acrylamido)butanamide 

Relevant academic research and scientific papers

Copper-catalyzed cross-coupling of amino acid-derived amides with (Z)-vinyl iodides: Unexpected solvent effect and preparation of plocabulin

A copper-catalyzed cross-coupling reaction of amino acid-derived amides and (Z)-vinyl iodide was studied to improve a key step in the synthesis of plocabulin, a novel microtubule destabilizer agent of marine origin. The study revealed a profound solvent effect with 1,2-dimethoxyethane (DME), which gave consistently high yields across a large variety of the amide and (Z)-vinyl iodide substrates. The protocol was successfully utilized in the preparation of plocabulin and provided a significantly improved yield.

Dihydropyrone compound and preparation method and purpose thereof

The invention belongs to the field of drug synthesis and relates to a novel dihydropyrone compound and a preparation method and a purpose thereof. The chemical formula of the dihydropyrone compound isshown in the following general formula I, biological ex

Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds

Microtubules continue to be one of the most successful anticancer drug targets and a favorite hit for many naturally occurring molecules. While two of the most successful representative agents in clinical use, the taxanes and the vinca alkaloids, come fro

ANTITUMORAL COMPOUNDS

A compound of general formula (I) wherein A, Y, W, R1, R2, R3, R4, R5, and R6 take various meanings for use in the treatment of cancer.

ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS

Antitumoral compounds of general formula (I) obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.