960211-45-4

Upstream product

• 960211-42-1 tert-butyl ((S)-1-(((S,1Z,6Z)-4-((tert-butyldiphenylsilyl)oxy)octa-1,6-dien-1-yl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate 
• 62965-35-9 N-tert-butyloxycarbonyl-L-tert-leucine 
• 960211-35-2 (S)-5-(but-2-yn-1-yl)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecane 
• 960211-36-3 (S,Z)-5-(but-2-en-1-yl)-2,2,9,9,10,10-hexamethyl-3,3-diphenyl-4,8-dioxa-3,9-disilaundecane 
• 960211-39-6 tert-butyl(((S,1Z,6Z)-1-iodoocta-1,6-dien-4-yl)oxy)diphenylsilane 
• 960211-37-4 (S,Z)-3-((tert-butyldiphenylsilyl)oxy)hept-5-en-1-ol 
• 960211-38-5 (S,Z)-3-((tert-butyldiphenylsilyl)oxy)hept-5-enal 
• 960211-10-3 (S)-1-((tert-butyldimethylsilyl)oxy)hept-5-yn-3-ol 
• 372199-21-8 (S)-tert-butyl (1-amino-3,3-dimethyl-1-oxobutan-2-yl)carbamate 

Downstream Products

• 960211-47-6 (S)-N-((S,1Z,6Z)-4-((tert-butyldiphenylsilyl)oxy)octa-1,6-dien-1-yl)-3,3-dimethyl-2-((Z)-3-(tributylstannyl)acrylamido)butanamide 

Relevant academic research and scientific papers

Copper-catalyzed cross-coupling of amino acid-derived amides with (Z)-vinyl iodides: Unexpected solvent effect and preparation of plocabulin

A copper-catalyzed cross-coupling reaction of amino acid-derived amides and (Z)-vinyl iodide was studied to improve a key step in the synthesis of plocabulin, a novel microtubule destabilizer agent of marine origin. The study revealed a profound solvent effect with 1,2-dimethoxyethane (DME), which gave consistently high yields across a large variety of the amide and (Z)-vinyl iodide substrates. The protocol was successfully utilized in the preparation of plocabulin and provided a significantly improved yield.

ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS

Antitumoral compounds of general formula (I) obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.