960211-39-6

Upstream product

• 960211-38-5 (S,Z)-3-((tert-butyldiphenylsilyl)oxy)hept-5-enal 
• 960211-37-4 (S,Z)-3-((tert-butyldiphenylsilyl)oxy)hept-5-en-1-ol 
• 3020-28-8 (iodomethyl)triphenylphosphonium iodide 

Downstream Products

• 960211-42-1 tert-butyl ((S)-1-(((S,1Z,6Z)-4-((tert-butyldiphenylsilyl)oxy)octa-1,6-dien-1-yl)amino)-3,3-dimethyl-1-oxobutan-2-yl)carbamate 
• 960211-45-4 (S)-2-amino-N-((1Z,6Z)-4-((tert-butyldiphenylsilyl)ox-y)octa-1,6-dien-1-yl)-3,3-dimethylbutanamide 
• 960211-47-6 (S)-N-((S,1Z,6Z)-4-((tert-butyldiphenylsilyl)oxy)octa-1,6-dien-1-yl)-3,3-dimethyl-2-((Z)-3-(tributylstannyl)acrylamido)butanamide 

Relevant academic research and scientific papers

Copper-catalyzed cross-coupling of amino acid-derived amides with (Z)-vinyl iodides: Unexpected solvent effect and preparation of plocabulin

A copper-catalyzed cross-coupling reaction of amino acid-derived amides and (Z)-vinyl iodide was studied to improve a key step in the synthesis of plocabulin, a novel microtubule destabilizer agent of marine origin. The study revealed a profound solvent effect with 1,2-dimethoxyethane (DME), which gave consistently high yields across a large variety of the amide and (Z)-vinyl iodide substrates. The protocol was successfully utilized in the preparation of plocabulin and provided a significantly improved yield.

Dihydropyrone compound and preparation method and purpose thereof

The invention belongs to the field of drug synthesis and relates to a novel dihydropyrone compound and a preparation method and a purpose thereof. The chemical formula of the dihydropyrone compound isshown in the following general formula I, biological ex

ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS

Antitumoral compounds of general formula (I) obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.