960221-97-0

Usage

Uses

Used in Organic Synthesis:
Tert-butyl 4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxylate is utilized as a building block in organic synthesis for its ability to contribute to the formation of complex molecular structures. Its stability and reactivity profile make it suitable for creating a variety of organic compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, tert-butyl 4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxylate is employed as a key component in the design and synthesis of pharmaceuticals. Its structural attributes allow it to be incorporated into drug molecules, potentially enhancing their therapeutic effects and pharmacological properties.
Used in Drug Development:
tert-butyl 4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxylate is also used in the development of new drugs, where its dihydroquinazolin-3(4H)-yl group may confer specific biological activities. The tert-butyl group's influence on stability and reactivity can be leveraged to improve drug candidates' performance in preclinical and clinical stages.
Used in Pharmaceutical Industry:
Tert-butyl 4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxylate is used as a precursor in the pharmaceutical industry for the synthesis of various drug substances. Its role in creating novel therapeutic agents is crucial, given its capacity to be modified and functionalized in multiple ways to achieve desired pharmacological effects.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 4403-69-4 2-amino-1-benzylamine 
• 87120-79-4 tert-butyl 4-((2-nitrobenzyl)amino)piperidine-1-carboxylate 
• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 552-89-6 2-nitro-benzaldehyde 
• 79098-98-9 tert-butyl 4-((2-aminobenzyl)amino)piperidine-1-carboxylate 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 79098-75-2 3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one 

Relevant academic research and scientific papers

1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to 1,3,4-oxadiazole derivative compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a therapeutic method using the composition, and a method for preparing the same, and the 1,3,4-oxadiazole derivative compounds are represented by a following chemical formula (I).

An efficient synthesis of the piperidinyl dihydroquinazolinone (PDQ) fragment of olcegepant

Olcegepant is one of the most potent and selective small molecule CGRP antagonists for the treatment of migraine headaches. Herein, we describe a new and efficient synthesis of the key piperidinyl dihydroquinazolinone (PDQ) fragment of olcegepant. PDQ plays a key role in the activity of CGRP antagonists. Primary improvements over existing methods include a high-yielding reductive amination step, greater overall yield, and operational simplicity. Coupling of PDQ to a D-tyrosine derivative effectively produced over one half of the total molecular structure of olcegepant. A unique tandem deprotection-nucleophilic addition sequence was also applied to the coupling of Fmoc-PDQ with phenyl isocyanate.

CGRP receptor antagonists

The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.

AMIDE-SUBSTITUTED ARYL PIPERIDINES

Amide-substituted aryl piperidines derivatives of the following Formulas are provided:(Formulas), in which the variables are as described herein. Such compounds may be used to modulate calcitonin gene-related peptide (CGRP) receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CGRP modulation in humans, domesticated companion animals and livestock animals, including headache, such as migraine. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such compounds for receptor localization studies and various in vitro assays.

BIARYL KETONE-SUBSTITUTED PIPERIDINES

Biaryl ketone-substituted piperidines of the following Formulas are provided:, and in which the variables are as described herein. Such compounds may be used to modulate calcitonin gene-related peptide (CGRP) receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CGRP modulation in humans, domesticated companion animals and livestock animals, including headache such as migraine. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such compounds for receptor localization studies and various in vitro assays.