Tert-butyl 4-(2-oxo-1,2-dihydroquinazolin-3(4H)-YL)piperidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 4-(2-oxo-1,2-dihydroquinazolin-3(4H)-YL)piperidine-1-carboxylate
CAS No.:960221-97-0
Molecular Formula:C18H25N3O3
Molecular Weight:331.415
Hs Code.:2933399990
DSSTox Substance ID:DTXSID60697031
Wikidata:Q82626841
Mol file:960221-97-0.mol

Synonyms:960221-97-0;TERT-BUTYL 4-(2-OXO-1,2-DIHYDROQUINAZOLIN-3(4H)-YL)PIPERIDINE-1-CARBOXYLATE;tert-butyl 4-(2-oxo-1,4-dihydroquinazolin-3-yl)piperidine-1-carboxylate;tert-Butyl 4-(2-oxo-1,2,3,4-tetrahydroquinazolin-3-yl)piperidine-1-carboxylate;SCHEMBL2604336;DTXSID60697031;ZWLBWQLDKIVVNR-UHFFFAOYSA-N;CS-M1096;tert-Butyl 4-(1,2-dihydro-2-oxoquinazolin-3(4H)-yl)piperidine-1-carboxylate;CS-13787;FT-0717537;A845533;tert-Butyl 4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carboxylate

Suppliers and Price of Tert-butyl 4-(2-oxo-1,2-dihydroquinazolin-3(4H)-YL)piperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
tert-Butyl4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxylate 95%
1g
$ 389.00

Alichem
Tert-butyl4-(2-oxo-1,2-dihydroquinazolin-3(4h)-yl)piperidine-1-carboxylate
5g
$ 2024.04

Alichem
Tert-butyl4-(2-oxo-1,2-dihydroquinazolin-3(4h)-yl)piperidine-1-carboxylate
1g
$ 694.72

Total 8 raw suppliers

Chemical Property of Tert-butyl 4-(2-oxo-1,2-dihydroquinazolin-3(4H)-YL)piperidine-1-carboxylate

Chemical Property:

PSA：65.37000
LogP:2.75860
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:331.18959167
Heavy Atom Count:24
Complexity:480

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1)N2CC3=CC=CC=C3NC2=O

Technology Process of Tert-butyl 4-(2-oxo-1,2-dihydroquinazolin-3(4H)-YL)piperidine-1-carboxylate

There total 6 articles about Tert-butyl 4-(2-oxo-1,2-dihydroquinazolin-3(4H)-YL)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 79098-98-9
tert-butyl 4-((2-aminobenzyl)amino)piperidine-1-carboxylate

: 530-62-1
1,1'-carbonyldiimidazole

: 960221-97-0
tert-butyl 4-(2-oxo-1,2,3,4-tetrahydroquinazolin-3-yl)piperidine-1-carboxylate

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 18h; Reflux;
DOI:10.1016/j.tetlet.2018.08.002

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 960221-97-0
tert-butyl 4-(2-oxo-1,2,3,4-tetrahydroquinazolin-3-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C

2: triethylamine / acetonitrile / 18 h / 20 °C / Reflux

With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2018.08.002

Reference yield:

: 4403-69-4
2-amino-1-benzylamine

: 960221-97-0
tert-butyl 4-(2-oxo-1,2,3,4-tetrahydroquinazolin-3-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 48 h / 20 °C

2: triethylamine / acetonitrile / 18 h / 20 °C / Reflux

With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2018.08.002