960241-14-9Relevant academic research and scientific papers
Solvent-free direct enantioselective aldol reaction using polystyrene-supported N-sulfonyl-(Ra)-binam-d-prolinamide as a catalyst
Banon-Caballero, Abraham,Guillena, Gabriela,Najera, Carmen
, p. 1599 - 1606 (2010)
The immobilization of N-sulfonyl-(Ra)-binam-d-prolinamide using polystyrene as a support allows the recovery of an efficient catalytic system for the enantioselective direct aldol reaction between different ketones and aldehydes under solvent-f
N-Tosyl-(Sa)-binam-L-prolinamide as highly efficient bifunctional organocatalyst for the general enantioselective solvent-free aldol reaction
Guillena, Gabriela,Nájera, Carmen,Viózquez, Santiago F.
experimental part, p. 3031 - 3035 (2009/10/16)
N-Tosyl-(Sa)-binam-L-prolinamide (5 mol%) and benzoic acid (1 mol%) were used as catalysts in the enantioselective direct aldol reaction between different ketones and aldehydes under solvent-free conditions in the presence or absence of water. Under these reaction conditions it was possible to reduce the amount of required ketone to two equivalents to give the corresponding aldol products with high yields, regio-, diastereo- and enantioselectivities. The aldol reaction between aldehydes or the intramolecular aldol reaction can be also performed with excellent results. Georg Thieme Verlag Stuttgart.
