96025-24-0

Upstream product

• 100-52-7 benzaldehyde 
• 173413-01-9 Dimethylthiocarbamoylmethyl-phosphonic acid diethyl ester 

Downstream Products

• 1186195-73-2 1-methyl-4-phenyl-pyrrolidine-2-thione 
• 1239955-48-6 (R)-N,N-dimethyl-3,5-diphenylpent-4-ynethioamide 
• 1239955-58-8 (R)-5-cyclopropyl-N,N-dimethyl-3-phenylpent-4-ynethioamide 
• 1239955-59-9 (R)-5-cyclohexyl-N,N-dimethyl-3-phenylpent-4-ynethioamide 
• 1239955-57-7 (R)-N,N-dimethyl-3-phenyldec-4-ynethioamide 
• 1239955-60-2 (R)-N,N,7-dimethyl-3-phenyloct-4-ynethioamide 
• 1239955-56-6 (R)-5-cyclohexenyl-N,N-dimethyl-3-phenylpent-4-ynethioamide 
• 1239955-61-3 (R)-N,N-dimethyl-3,7-diphenylhept-4-ynethioamide 

Relevant academic research and scientific papers

Functionalised α,β-Unsaturated Thioamides via Horner-Emmons Reactions

The reaction of a phosphonodithioacetate with amines (in particular functionalised amines) leads to thiocarbamoylmethylphosphonates (unsubstituted at the carbon α to the phosphoryl group), which can be used as Horner-Emmons reagents.This pathway is a very convenient and general synthesis of functionalised thiocarbamoylphosphonates and α,β-unsaturated thioamides (in particular new amino acid derivatives).