96026-67-4Relevant academic research and scientific papers
Solid-phase synthesis and on-column deprotection of RNA from 2′- (and 3′-) O-Levulinated (Lv) ribonucleoside monomers
Lackey, Jeremy G.,Sabatino, David,Damha, Masad J.
, p. 789 - 792 (2008/01/27)
(Chemical Equation Presented) The solid-phase synthesis of oligoribonucleotides derived from ribonucleosides esterified at the 2′ (or 3′-) position with the levulinyl (Lv) group is described. The oligomers can be released from the solid support as 2′-O-Lv
Hydrolytic stability of a phosphate-branched oligonucleotide incorporating a ribonucleoside 3′-phosphotriester unit
Loennberg, Tuomas
, p. 315 - 323 (2007/10/03)
A phosphate-branched oligonucleotide has been prepared by using an appropriately protected trinucleoside phosphotriester building block in conventional solid-phase synthesis. Hydrolysis of the branched oligonucleotide has been followed over a wide pH range. Comparison of the present results with those previously obtained for simpler analogues indicates that a trinucleoside 3′,3′,5′-monophosphate, when embedded in an oligonucleotide structure, is stabilized toward hydroxide-ion catalyzed cleavage by more than one order of magnitude, lending some support to the feasibility of existence of phosphate-branched RNA X in biological systems. Copyright Taylor & Francis Group, LLC.
