960357-30-6Relevant academic research and scientific papers
Phenyl trimethyl ammonium tribromide mediated robust one-pot synthesis of spiro-oxacycles-an economic route-stereoselective synthesis of oxaspirohexacyclodieneones
Sarkar, Debayan,Ghosh, Manoj Kumar,Rout, Nilendri
, p. 7883 - 7898 (2016/08/30)
This paper entails the first recognition of Phenyl Trimethyl Ammonium Tribromide (PTAB) as an effective reagent for spiro-cyclizations proceeding via oxidative dearomatization. The experiment exhibits economical, metal and ligand free one-pot accomplishment of these significant transformations. The described protocol presents the first generalised methodology of spiro-oxacycle synthesis which can be applied towards various directions. A stereoselective synthesis of oxa-spirocyclooxadieneones has been accomplished.
