960365-81-5Relevant academic research and scientific papers
Enantioselective synthesis of the complex rocaglate (-)-silvestrol
Gerard, Baudouin,Cencic, Regina,Pelletier, Jerry,Porco Jr., John A.
, p. 7831 - 7834 (2008/09/19)
The total synthesis of the natural product (-)-silvestrol (1) has been accomplished and features enantioselective [3+2] photocycloaddition of a substituted 3-hydroxyflavone and methyl cinnamate promoted by a chiral Bronsted acid. Initial biological studies indicate a 5-10-fold greater activity of silvestrol as an inhibitor of protein synthesis in HeLa cells than its 1″″ diastereomer.
