960378-74-9Relevant academic research and scientific papers
Cyclometalated Iridium(III) Imidazole Phenanthroline Complexes as Luminescent and Electrochemiluminescent G-Quadruplex DNA Binders
Castor, Katherine J.,Metera, Kimberly L.,Tefashe, Ushula M.,Serpell, Christopher J.,Mauzeroll, Janine,Sleiman, Hanadi F.
, p. 6958 - 6967 (2015)
Six cyclometalated iridium(III) phenanthroimidazole complexes with different modifications to the imidazole phenanthroline ligand exhibit enhanced luminescence when bound to guanine (G-) quadruplex DNA sequences. The complexes bind with low micromolar affinity to human telomeric and c-myc sequences in a 1:1 complex:quadruplex stoichiometry. Due to the luminescence enhancement upon binding to G-quadruplex DNA, the complexes can be used as selective quadruplex indicators. In addition, the electrogenerated chemiluminescence of all complexes increases in the presence of specific G-quadruplex sequences, demonstrating potential for the development of an ECL-based G-quadruplex assay. (Chemical Equation Presented).
A mitochondria-targeted iridium(III)-based photoacid generator induces dual-mode photodynamic damage within cancer cells
He, Liang,Zhang, Ming-Fang,Pan, Zheng-Yin,Wang, Kang-Nan,Zhao, Zi-Jian,Li, Yi,Mao, Zong-Wan
supporting information, p. 10472 - 10475 (2019/09/07)
A mitochondria-targeted photodynamic therapy (PDT) agent was designed and synthesized. Upon light irradiation, it can produce photoacid and its photolysis products can further sensitize 1O2 generation, causing dual-mode (oxygen-indep
Visible-light harvesting with cyclometalated iridium(III) complexes having long-lived 3IL excited states and their application in triplet-triplet-annihilation based upconversion
Sun, Jifu,Wu, Wanhua,Guo, Huimin,Zhao, Jianzhang
, p. 3165 - 3173 (2011/08/07)
Cyclometalated iridium(III) complexes with intense absorption in the visible region (Iμ = 70920 M-1 cm-1 at 466 nm) were prepared by incorporating light-harvesting coumarin into the diimine ligand (for comparison: Iμ = 7030 M-1 cm-1 at 371 nm for the model diimine complex without light-harvesting ability). The complexes feature long-lived intraligand triplet excited states (3IL, supported by spin density analysis of the triplet state). At room temperature, lifetimes, τT, are up to 75.5 μs, as determined by nanosecond time-resolved transient absorption spectroscopy. Despite the weak phosphorescence (φP = 0.6-0.7 %) observed for the complexes, the triplet excited state (T1) was demonstrated to be efficiently populated upon photoexcitation, by using the complexes as triplet sensitizers in triplet-triplet-annihilation (TTA) upconversion (upconversion quantum yields, φUC, are up to 23.4 %). We propose that weakly phosphorescent or even nonphosphorescent transition metal complexes can be used as triplet sensitizers for TTA upconversion, instead of the currently used phosphorescent complexes. Our design of the light-harvesting IrIII complexes will be helpful for the preparation of transition metal complexes with intense absorption of visible light and long-lived triplet excited states, which are suitable for applications in areas such as photocatalysis, photovoltaics, and upconversion.
