960595-42-0Relevant academic research and scientific papers
Enantioselective construction of quaternary stereogenic carbon atoms by the lewis base catalyzed additions of silyl ketene imines to aldehydes
Denmark, Scott E.,Wilson, Tyler W.,Burk, Matthew T.
supporting information, p. 9268 - 9279 (2014/08/05)
Silyl ketene imines derived from a variety of α-branched nitriles have been developed as highly useful reagents for the construction of quaternary stereogenic centers via the aldol addition reaction. In the presence of SiCl4 and the catalytic a
A new synthesis of pyrrolidines by way of an enantioselective Mannich/diastereoselective hydroamination reaction sequence
Baxter Vu, Jenny M.,Leighton, James L.
, p. 4056 - 4059 (2011/09/21)
A new two-step synthesis of highly substituted pyrrolidines has been developed. Chiral silane Lewis acid promoted enantioselective Mannich reactions of silyl ketene imines with acylhydrazones may be used to access bishomoallylic benzoic hydrazides that in
