96072-57-0Relevant academic research and scientific papers
A highly efficient nucleophilic substitution reaction between R2P(O)H and triarylmethanols to synthesize phosphorus-substituted triarylmethanes
Chen, Long,Fang, Xin-Yue,Zou, Yun-Xiang
supporting information, p. 951 - 956 (2018/02/19)
A highly efficient and general nucleophilic substitution reaction between dialkyl H-phosphonates or diarylphosphine oxides and triarylmethanols catalyzed by HOTf (trifluoromethanesulfonic acid) has been developed. It provides an atom-economical protocol for the synthesis of various symmetrical and unsymmetrical phosphorus-substituted triarylmethanes that constitute an emerging family of potent anticancer agents in rich diversity with 40 to 96% yields. The synthetic applicability of this protocol is demonstrated by gram-scale preparations.
The complex role of the triphenylmethyl motif in anticancer compounds
Palchaudhuri, Rahul,Nesterenko, Vitaliy,Hergenrother, Paul J.
supporting information; experimental part, p. 10274 - 10281 (2009/02/04)
Compounds incorporating the triphenylmethyl motif constitute an emerging family of potent anticancer agents. Although several small molecules containing this pharmacophore have now been identified, the mechanism of cell death induction for some of these c
