96080-94-3

Upstream product

• 104090-76-8 2-(hexyloxy)benzothiomorpholide 
• 90-02-8 salicylaldehyde 
• 7162-59-6 2-hexyloxybenzaldehyde 
• 111-25-1 1-bromo-hexane 
• 104090-77-9 2-Hexyloxy-dithiobenzoic acid methyl ester 

Downstream Products

• 104090-78-0 2-(chloromethyl)-5-<2-(hexyloxy)phenyl>-1,3,4-thiadiazole 
• 104090-65-5 C-[5-(2-Hexyloxy-phenyl)-[1,3,4]thiadiazol-2-yl]-methylamine 
• 104090-66-6 2-<2-(hexyloxy)phenyl>-5-<(methylamino)methyl>-1,3,4-thiadiazole 

Relevant academic research and scientific papers

Substituted 1,3,4-Thiadiazoles with Anticonvulsant Activity. 2. Aminoalkyl Derivatives

This paper describes the synthesis and pharmacological evaluation of a number of substituted 1,3,4-thiadiazoles.The first member of the series, 2-(aminomethyl)-5-(2-biphenylyl)-1,3,4-thiadiazole (7) was found to possess potent anticonvulsant properties in rats and mice and compared favorably with the standard anticonvulsant drugs phenytoin, phenobarbital, and carbamazepine in a number of test situations.The potency of compound 7 was maintained on alkylation of the side-chain nitrogen atom; however, aryl substitution or chain lengthening caused a drop in potency.Replacement of the 2-biphenylyl group by phenyl or benzyl also lead to inactive compounds.