96087-08-0

Basic information

• Product Name: methyl threo-3-<(5-chloro-2-nitrophenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propionate
• Synonyms: methyl threo-3-<(5-chloro-2-nitrophenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propionate
• CAS NO: 96087-08-0
• Molecular Weight: 397.836
• Mol File: 96087-08-0.mol

Chemical Properties

• CAS DataBase Reference: methyl threo-3-<(5-chloro-2-nitrophenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl threo-3-<(5-chloro-2-nitrophenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propionate(96087-08-0)
• EPA Substance Registry System: methyl threo-3-<(5-chloro-2-nitrophenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propionate(96087-08-0)

Safety Data

• Hazardous Substances Data: 96087-08-0(Hazardous Substances Data)

Upstream product

• 14371-79-0 2-nitro-5-chlorothiophenol 
• 96125-49-4 methyl trans-3-(4-methoxyphenyl)glycidate 

Downstream Products

• 96125-21-2 3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 
• 120701-21-5 4-Methyl-benzoic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester 
• 100893-31-0 Acetic acid (2R,3R)-5-[2-(benzyl-methyl-amino)-ethyl]-8-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester 
• 100893-24-1 (2R,3R)-5-[2-(Benzyl-methyl-amino)-ethyl]-8-chloro-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 130884-75-2 (+/-)-cis-<<(n-butylamino)carbonyl>oxy>-8-chloro-5-<2-(dimethylamino)ethyl>-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 
• 96125-28-9 Acetic acid (2R,3R)-8-chloro-2-(4-methoxy-phenyl)-5-[2-(methyl-propyl-amino)-ethyl]-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester 
• 130884-48-9 Carbonic acid (2R,3R)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester ethyl ester 
• 96142-59-5 Acetic acid (2R,3R)-8-chloro-5-[2-(ethyl-methyl-amino)-ethyl]-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester 
• 96087-06-8 (2R,3R)-8-Chloro-3-hydroxy-2-(4-methoxy-phenyl)-5-[2-(methyl-propyl-amino)-ethyl]-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 96451-06-8 (+/-)-cis-3-acetoxy-8-chloro-5-<2-(dimethylamino)ethyl>2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 
• 130884-76-3 8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-methoxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 105487-94-3 (2R,3R)-8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 105487-93-2 (2RS,3RS)-8-chloro-5-<2-(dimethylamino)ethyl>-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 
• 96125-51-8 (+/-)-threo-3-<(2-amino-5-chlorophenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propionic acid 

Relevant articles and documents

Synthesis of Halogen-Substituted 1,5-Benzothiazepine Derivatives and Their Vasodilating and Hypotensive Activities

In an attempt to improve the effectiveness and duration of the action of diltiazem (1), a 1,5-benzothiazepine calcium channel blocker, its derivatives (2) with halogen substituents on the fused benzene ring were synthesized.These compounds were evaluated for their effects on vertebral and coronary blood flows and antihypertensive activity.The structure-activity relationships are discussed.The 8-chloro derivative ((+)-2b), the most potent compound in this series, was selected for clinical evaluation as a cerebral vasodilating and antihypertensive agent.