96093-41-3

Upstream product

• 77943-39-6 4-methyl-5-phenyloxazolidin-2-one 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 1609532-32-2 (4R,5S)-3-(dibenzylglycyl)-4-methyl-5-phenyloxazolidin-2-one 
• 96021-75-9 (4R,5S)-3-(2-Ethoxy-acetyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 96021-68-0 (4R,5S)-N-(diazoacetyl)-4-methyl-5-phenyloxazolidone 
• 96039-46-2 3-((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-oxazolidine-2,4-dione 
• 177659-46-0 [(1S,2R)-1-((S)-sec-Butyl)-2-hydroxy-4-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-4-oxo-butyl]-methyl-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Electrogenerated base-induced N-acylation of chiral oxazolidin-2-ones. 2

An improved and efficient electrochemical N-acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addition of base or probase, by direct electrolysis of a solution of Me

Dolastatins 23: Stereospecific synthesis of dolaisoleuine

The remarkable antineoplastic peptide dolastatin 10, isolated from the opisthobranchia mollusc Dolabella auricularia, is currently in clinical development and further improvements in its total synthesis have been undertaken. Major effort has been directed at devising more stereoselective routes to the dolastatin 10 amino acid units dolaisoleuine 2 and dolaproine 3, each bearing three chiral centres. We report herein highly stereoselective routes to both natural (3R,4S,5S)-dolaisoleuine 2 and its 3S,4S,5S-isomer 14 (Z replaces H) using an asymmetric aldol methodology. Key reaction steps are condensation of chiral α-(methylsulfanyl)acetyloxazolidinone 4d with (S)-N-Z-N-Me-isoleucinal 6 using dibutylboron triflate followed by reductive desulfurization, O-methylation and cleavage of the oxazolidinone auxiliary to complete a simple route to N-benzyloxycarbonyldolaisoleuine 10. By substituting chiral oxazolidinone 5d for 4d the 3S-isomer of N-benzyloxycarbonyldolaisoleuine 14 was selectively obtained.

Biosynthesis of Tetronasin: Part 3. Preparation of Deuterium Labelled Tri- and Tetraketides as Putative Biosynthetic Precursors of Tetronasin

The preparation of seven deuterium labelled N-acetyl cysteamine thioesters (2a), (2b), (3a), (3b), (4), (5) and (6) as putative biosynthetic precursors of the acyl tetronic acid ionophore tetronasin is described.