961-31-9Relevant articles and documents
Fe-catalyzed Fukuyama-type indole synthesis triggered by hydrogen atom transfer
Huang, Hanmin,Yu, Min,Zhang, Tianze
, p. 10501 - 10505 (2021/08/20)
Fe, Co, and Mn hydride-initiated radical olefin additions have enjoyed great success in modern synthesis, yet the extension of other hydrogen radicalophiles instead of olefins remains largely elusive. Herein, we report an efficient Fe-catalyzed intramolec
Green synthesis method of 3-sulfonylmethyl-1H-indole compound
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Paragraph 0032-0047, (2020/12/30)
The invention discloses a green synthesis method of a 3-sulfonylmethyl-1H-indole compound. The structure of the 3-sulfonylmethyl-1H-indole compound is shown as a formula I, the preparation method comprises the following steps: taking an R1 substituted 3-indole acetic acid compound and an R2 substituted sodium sulfinate compound as raw materials, adopting a copper catalyst, taking N, N-dimethylformamide or dimethyl sulfoxide as a solvent, carrying out nitrogen protection, and carrying out a heating reaction to generate the 3-sulfonylmethyl-1H-indole compound shown in the formula I. According tothe method disclosed by the invention, N, N-dimethylformamide or dimethyl sulfoxide is used as a solvent, and a copper catalyst is adopted, so that the use of an expensive or complex catalyst is avoided; the reaction conditions are mild, the reaction process is simple, and the green chemistry concept is met; the post-treatment of the reaction is simple, and the high-purity 3-sulfonylmethyl-1H-indole compound can be obtained only by simple extraction, concentration and column chromatography.
