961-31-9Relevant academic research and scientific papers
Fe-catalyzed Fukuyama-type indole synthesis triggered by hydrogen atom transfer
Huang, Hanmin,Yu, Min,Zhang, Tianze
, p. 10501 - 10505 (2021/08/20)
Fe, Co, and Mn hydride-initiated radical olefin additions have enjoyed great success in modern synthesis, yet the extension of other hydrogen radicalophiles instead of olefins remains largely elusive. Herein, we report an efficient Fe-catalyzed intramolec
Green synthesis method of 3-sulfonylmethyl-1H-indole compound
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Paragraph 0032-0047, (2020/12/30)
The invention discloses a green synthesis method of a 3-sulfonylmethyl-1H-indole compound. The structure of the 3-sulfonylmethyl-1H-indole compound is shown as a formula I, the preparation method comprises the following steps: taking an R1 substituted 3-indole acetic acid compound and an R2 substituted sodium sulfinate compound as raw materials, adopting a copper catalyst, taking N, N-dimethylformamide or dimethyl sulfoxide as a solvent, carrying out nitrogen protection, and carrying out a heating reaction to generate the 3-sulfonylmethyl-1H-indole compound shown in the formula I. According tothe method disclosed by the invention, N, N-dimethylformamide or dimethyl sulfoxide is used as a solvent, and a copper catalyst is adopted, so that the use of an expensive or complex catalyst is avoided; the reaction conditions are mild, the reaction process is simple, and the green chemistry concept is met; the post-treatment of the reaction is simple, and the high-purity 3-sulfonylmethyl-1H-indole compound can be obtained only by simple extraction, concentration and column chromatography.
Copper-Mediated Decarboxylative Sulfonylation of Arylacetic Acids with Sodium Sulfinates
Wu, Yinrong,Chen, Jiewen,Li, Lu,Wen, Kangmei,Yao, Xingang,Pang, Jianxin,Wu, Ting,Tang, Xiaodong
supporting information, p. 7164 - 7168 (2020/10/02)
Herein, we present a copper-mediated decarboxylative sulfonylation of arylacetic acids with sodium sulfinates that provides viable access to sulfone compounds. This protocol features readily available feedstocks, simple operations, high regioselectivities, and moderate to good yields. The newly obtained products could be converted to other useful compounds. Importantly, the products and their derivatives exhibited potent antitumor activities in vitro, which were tested by MTT assay.
