96100-54-8Relevant academic research and scientific papers
Kinetics and mechanism of gas-phase pyrolysis of N-aryl-3-oxobutanamide ketoanilides, their 2-arylhydrazono derivatives, and related compounds
Malhas, Rana N.,Al-Awadi, Nouria A.,El-Dusouqui, Osman M.E.
, p. 82 - 91 (2007)
Rates and products of reaction and Arrhenius activation parameters were determined for the gas-phase thermolysis of 14 substrates of the title compounds using sealed pyrex reactor tubes and HPLC/UV-VIS to monitor substrate pyrolysis. The 14 compounds under study are N-phenyl-3-oxo- (1), N-(p-chlorophenyl)-3-oxo- (2). N-(p-methylphenyl)-3-oxo- (3). and N-(p-methoxyphenyl)-3-oxobutanamide (4). in addition to (i) four substrates (5-8) obtained by the replacement of the pairs of methylene hydrogens at the 2-position of compounds (1-4), each pair by a phenylhydrazono group; (ii) three arylhydrazono derivatives (9-11) in which Cl, CH3, or OCH3 groups are substituted at the para position of the phenylhydrazono moiety of compound 5, (iii) 3-oxobutanamide (acetoacetamide. 12), N-phenyl-3-oxo-3- phenylpropanamide (13), and N,N′-diphenylpropanediamide (14). The reactions were conducted over 374-546 K temperature range, and the values of the Arrhenius log A(s-1) and Ea(kJ mol-1) of these reactions were, respectively, 120±2.0 and 119.2 ± 17.0 for the ketoanilides (1-4, 12-14), and 13.0 ± 0.7 and 157.5 ± 8.6 for the arylhyrazono compounds (5-11). Kinetically. the arylhydrazono derivatives were found to be ca. 1.4 × 103 to 5.7 × 103 times less reactive than the parent ketoanilides. A mechanism is proposed to account for reaction products and to rationalize molecular reactivities.
Synthesis, characterization, and biological studies of some novel pyrazole carboxamide, pyridazine and thienopyridazine derivatives
Hussein, Abdel Haleem M.,Othman, Ismail M. M.
, (2019)
The arylhydrazones 3a, b were prepared and reacted with various reagents to yield the target compounds pyrazoles 6a–f, 1,6-dihydropyridazine-3-carboxamide derivatives 9a,b and thieno[3,4-d]pyridazine-1-carboxamide derivatives 10a,b. The structures of the synthesized compounds were confirmed by various spectral data and elemental analyses. Furthermore, all target derivatives were tested for their antibacterial bioactivity against different types of Gram+?ve and Gram-ve strains and for antifungal activity against two fungi micro-organisms by well diffusion method. Thus, the observed results showed that the 5-cyano-6-imino-N-(4-methoxyphenyl)-4-methyl-1-phenyl-1,6-dihydropyridazine-3-carboxamide (9b) displayed the best antimicrobial activity (with MIC values ranged from 0.49 ± 0.2 to 3.9 ± 0.6 μg/mL).
