96107-03-8

Upstream product

• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 555-16-8 4-nitrobenzaldehdye 
• 421-50-1 1,1,1-trifluoro-2-propanone 

Downstream Products

• 1017536-06-9 (S)-4-(trifluoromethyl)-4-hydroxy-6-(p-nitrophenyl)hex-5-en-2-one 
• 1037590-16-1 4-(4-nitrophenyl)-6-(trifluoromethyl)-2H-pyran-2-one 
• 948057-05-4 (E)-3-[2-(4-chlorophenyl)ethynyl]-1,1,1-trifluoro-4-(4-nitrophenyl)but-3-en-2-ol 
• 948056-97-1 (E)-1,1,1-trifluoro-4-(4-nitrophenyl)-3-(2-phenylethynyl)but-3-en-2-ol 
• 948056-89-1 (Z)-1,1,1-trifluoro-3-iodo-4-(4-nitrophenyl)but-3-en-2-ol 
• 948056-79-9 1,1,1-trifluoro-3-iodo-4-(4-nitrophenyl)but-3-en-2-one 

Relevant academic research and scientific papers

Reaction of 1,2-unsaturated trifluoromethyl ketones and their conversion to 1-(trifluoromethyl)furan derivatives

A novel synthetic approach leading to 1-(trifluoromethyl)furan derivatives is reported. 4-Aryl-1,1,1-trifluorobut-3-en-2-one was iodinated and subsequently reduced to give the corresponding alcohol. The resultant iodo compound was then subjected to coupli

A convenient one-pot synthesis of 6-trifluoromethyl-pyridines

α,β-Unsaturated trifluoromethyl ketones (1) react with primary enamines (2) such as β-aminocrotononitrile and β-aminocrotonates in the presence of phosphorus oxychloride / pyridine adsorbed on silica gel and manganese dioxide, providing good to high yield

Methyl vs. Methylene Condensation of Aromatic Aldehydes with 1,1,1-Trifluoroacetylacetone

From the slow Knoevenagel condensations of 1,1,1-trifluoroacetylacetone (4) with aromatic aldehydes in benzene in the presence of piperidine-AcOH, low yields of three products were isolated: the enol form of the methyl-condensation product ArCH=CHCOCH=C(O