96110-89-3

Upstream product

• 394-47-8 2-fluorobenzonitrile 
• 99918-44-2 N-(4-chlorophenyl)piperidin-4-amine dihydrochloride 
• 106-47-8 4-chloro-aniline 
• 37656-66-9 4-chloro-N-(1-ethoxycarbonyl-4-piperidinyl)aniline 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 

Downstream Products

• 93592-56-4 7-chloro-1,3-dihydro-5-(2-fluorophenyl)-1-(4-piperidinyl)-2H-1,4-benzodiazepin-2-one 

Relevant academic research and scientific papers

Aminohaloborane in Organic Synthesis. IX. Exclusive ortho Acylation Reaction of N-Monoaminoalkylanilines

The exclusive ortho acylation reaction of aniline derivatives using boron trichloride made possible the one-step synthesis of 2-acyl-N-monoaminoalkylanilines (1) and the corresponding imines (2) from N-monoaminoalkylanilines, even in the case of compounds with a bulky substituent at the nitrogen atom.Conventional methods only give 1 via elaborate procedures.Keywords: regioselective reaction; 2-acylaniline derivative; 2-acylaniline-imine derivative; boron trichloride