99918-44-2

Upstream product

• 37656-66-9 4-chloro-N-(1-ethoxycarbonyl-4-piperidinyl)aniline 
• 106-47-8 4-chloro-aniline 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 
• 401565-95-5 1-(tert-Butoxycarbonyl)-4-[(4-chlorophenyl)amino]piperidine 

Downstream Products

• 96110-89-3 {4-Chloro-2-[(2-fluoro-phenyl)-imino-methyl]-phenyl}-piperidin-4-yl-amine 

Relevant academic research and scientific papers

QUINOXALINE DERIVATIVES AS GPR6 MODULATORS

The present invention provides compounds of Formula (I) that are GPR6 modulators and are therefore useful for the treatment of diseases treatable by modulation of GPR6, in particular treating Parkinson disease, levodopa induced dyskinesias, Huntington's disease, other dyskinesias, akinesias, and motor disorders involving dysfunction of the striatum, schizophrenia and drug addiction. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Aminohaloborane in Organic Synthesis. IX. Exclusive ortho Acylation Reaction of N-Monoaminoalkylanilines

The exclusive ortho acylation reaction of aniline derivatives using boron trichloride made possible the one-step synthesis of 2-acyl-N-monoaminoalkylanilines (1) and the corresponding imines (2) from N-monoaminoalkylanilines, even in the case of compounds with a bulky substituent at the nitrogen atom.Conventional methods only give 1 via elaborate procedures.Keywords: regioselective reaction; 2-acylaniline derivative; 2-acylaniline-imine derivative; boron trichloride